Friday, January 24, 2020

The Mystery of Style :: Plays Mysteries Essays

The Mystery of Style Introduction: There has been a fight in a bar and a person was killed. Through the investigation the detective is bringing forth testimonies that give clues to who the people are (what they do). It is the up to the audience to guess what Jill, Tony and Robert do. Characters: Detective Joe Jill Tony Robert -------------------------------------------------------------------------------- A bar set back, stage left. Three or four tables set in various places on stage. Lighting is dim. One table and two chairs, close to stage right, have been knocked over. Light rock music is heard. Lighting is dim. The bartender is wiping a glass or serving a drink. There is a customer at the bar and two at tables. Lights become brighter. Detective enters stage right - he is writing in his notebook. The music quiets. Detective: [walking toward the bar] Coffee Joe? Joe: [reaches under the bar for a cup and the coffeepot] Sure thing. Detective: [taking the cup of coffee and turning toward the people at the tables] O.k. folks. I just have to ask you a few questions and then you can leave. [looks at Jill] IÕll start with you. Jill: [looks uncomfortable] I'll tell you what I can officer, but I really don't know much. Detective: [sits down across from her at the table] That's fine ma'am. Any information you can give me right now will help. [notices Jill is uncomfortable] Now just relax and tell me what you saw. Jill: [tries to relax, takes a drink from her glass] Well, I must tell you first of all that I don't normally visit this sort of place but my husband and two children are on a camping trip... they went up north... anyway, my friend Darla calls me and talks me into meeting her at this place for one drink. She says I need to get out more but I knew I should have stayed home... Detective: Could you please just tell me about the incident in question ma'am? Jill: Sorry officer [fidgets in her chair] Anyway, as I said, I was here to meet Darla - who never arrived- and I was just about to leave when this big guy comes in and goes up to the little guy, who was sitting at that table by the door, and begins shouting at him. They began to shout back and forth and calling each other names - [leans closer to Detective] I don't have to repeat the names do I officer?

Thursday, January 16, 2020

Over The Last Few Years Essay

Over the last few years, social networking has become the newest trend. There are few main ideas that people take social net seriously. At first social networking at school and colleges help students and teachers play an important role in order to improve their abilities. Then it helps us to with reconnecting with people and finally it offers some useful services among friends and families as we create good environment by text messaging, games among others etc. The invention of the social networking has everyone running towards the technology. It has become so popular that really everyone is using whether it is the new generation who know everything about technology or the people who are barely starting to use the internet. People are attached to it because you can communicate with people from all over the world at any time of the day to anywhere you are, you can connect thru the internet. But the internet is not so great; there are many advantages and disadvantages of social networking. Social networking sites like Facebook, Twitter, and Instagram help people share their feelings, thoughts and find out more about their friends’ interests, as well as their personal lives. At the same time putting your personal information such as your name, age, location, gender and many other types of information that you may not want to let others know can be insecure. Also these networking sites can get addiction that often users’ hours and troubles their performance in other grounds. Therefore social networking can be part of everyday life because it has brought revolutionary changes among people. Knowing how to use it wisely and effectively utilize will only enhance our social lives and change for the better.

Tuesday, January 7, 2020

The Therapeutic Options For Treating Type 2 Diabetes Mellitus

The therapeutic options for treating type 2 diabetes mellitus (T2DM) have been widened since April 2005 due to the introduction of Exenatide, the first incretin mimetic (Bond 2006). Due to the prevalence of this disease, the largest and most powerful pharmaceutical companies are ambitious to develop effective therapeutic methods. Exenatide is a synthetic peptide that was first identified in the saliva of Heloderma Suspectum, a species of venomous lizard native to areas in the United States and Mexico (Kalra 2013). In this review, the focus is on the mechanisms of exenatide and how these may relate to therapeutic responses . The exact mechanisms of Exenatide are continually under investigation with certain evaluations focusing on the†¦show more content†¦The synthetic preparation Exenatide targets the GLP-1 receptor (GLP-1R) and acts as an agonist which elicits action of the GLP-1 pathway while displaying other antihyperglycemic actions (McDougal, McKay Fisher 2011). Re actions of an active GLP-1 pathway typically lead to insulin secretion by the beta cells and the suppression of inadvertently elevated glucagon secretion (Iltz, 2006). The Active Pharmaceutical Ingredient (API), has been proven clinically to elicit favourable responses on patient; glucose-dependent insulin secretion, first-phase insulin response, glucagon secretion, gastric emptying and food intake (Derosa et.al, 2010). Exenatide preparations are made by incorporating molecules into a matrix of poly-D, L-lactide-co-glycolide which, although similar to the native glucagon-like peptide has a much longer duration of action (Kalra 2013). The finished dosage form is a pre-filled syringe, which contains the liquid dosage. The drug should be administered subcutaneously by injection, after a period of 60 minutes, prior to consuming morning and afternoon meals. These dosage times are critical for maintaining efficacy and clinical significance as the drug slows the rate of gastric emptying, reducing the rate of meal derived glucose (Bond 2006). Studies A study conducted by Buse et al (2007) examined the metabolic effects of 2 years of exenatide treatment in patients with T2DM. The results of their study showed HbA(1c) levels were